- Title
- Unraveling the complexity of therapeutic drug monitoring for monoclonal antibody therapies to individualize dose in oncology
- Creator
- Chatelut, Etienne; Hendrikx, Jeroen J. M. A.; Martin, Jennifer; Ciccolini, Joseph; Moes, Dirk Jan A. R.
- Relation
- Pharmacology Research & Perspectives Vol. 9, Issue 2, no. e00757
- Publisher Link
- http://dx.doi.org/10.1002/prp2.757
- Publisher
- John Wiley & Sons
- Resource Type
- journal article
- Date
- 2021
- Description
- Monoclonal antibodies (Mabs) have become key drugs in cancer treatment, either as targeted therapies or more recently as immune checkpoint inhibitors (ICIs). The fact that only some patients benefit from these drugs poses the usual question in the field of onco-hematology: that of the benefit of individual dosing and the potential of therapeutic drug monitoring (TDM) to carry out this individualization. However, Mabs present unique pharmacological characteristics for TDM, and the pharmacokinetic-pharmacodynamic relationship observed should be interpreted differently than that observed for conventional drugs and small molecules. This pharmacology practice review has been summarized from a public debate between the authors at the International TDM and Clinical Toxicology meeting in Banff, 2020, regarding the potential roles of TDM in the Mab/ICI setting.
- Subject
- oncology; key drugs; immune checkpoint inhibitors; patients; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1454620
- Identifier
- uon:44977
- Identifier
- ISSN:2052-1707
- Rights
- © 2021 The Authors. Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- Language
- eng
- Full Text
- Reviewed
- Hits: 1927
- Visitors: 2005
- Downloads: 99
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 1022 KB | Adobe Acrobat PDF | View Details Download |